Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas maltophilia on β-Lactam Resistance.

نویسندگان

  • Simon Devos
  • Stephan Stremersch
  • Koen Raemdonck
  • Kevin Braeckmans
  • Bart Devreese
چکیده

The treatment ofStenotrophomonas maltophiliainfection with β-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomally encoded β-lactamases. Here, we show that these β-lactamase-packed OMVs are capable of establishing extracellular β-lactam degradation. We also show that they dramatically increase the apparent MICs of imipenem and ticarcillin for the cohabituating speciesPseudomonas aeruginosaandBurkholderia cenocepacia.

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The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 60 4  شماره 

صفحات  -

تاریخ انتشار 2016